cp 10 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13627	CP-10		CDK
	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpre...		CDK
T4014	CP-724714	CP724714,CP 724714	Apoptosis , EGFR
	CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.		Apoptosis , EGFR
T6091	CP-673451		VEGFR , PDGFR , c-Kit
	CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.		VEGFR , PDGFR , c-Kit
T6455	CP-91149		Phosphorylase
	CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.		Phosphorylase
T8425	Linoleoyl Ethanolamide		TRP/TRPV Channel
	Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.		TRP/TRPV Channel
T18515	Palbociclib-propargyl	PROTAC CDK6 ligand 1	Others
	Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].		Others
T17904	Pomalidomide-PEG1-C2-N3	E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13	Others
	Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are common...		Others
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific bindi...

Compounds

CP-10

T13627

Synonym: CP724714,CP 724714

Target: Apoptosis, EGFR

CP-673451

T6091

Synonym:

Target: VEGFR, PDGFR, c-Kit

CP-91149

T6455

Synonym:

Target: Phosphorylase

Linoleoyl Ethanolamide

T8425

Synonym:

Target: TRP/TRPV Channel

Palbociclib-propargyl

T18515

Synonym: PROTAC CDK6 ligand 1

Target: Others

Pomalidomide-PEG1-C2-N3

T17904

Synonym: E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01356	S100A8 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	S100A8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is P05109.
TMPY-03556	S100A8 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	S100A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P27005.
TMPJ-00991	S100A8 Protein, Rat, Recombinant (His)	Rat	E. coli
	Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytop...
TMPY-02300	BIN1 Protein, Human, Recombinant (His)	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicat...
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-00961	ADAM15 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.